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What do you need to know about Sertraline Side

AntidepressantsTreatment & Care

What do you need to know about Sertraline Side

ChildPsy
By
ChildPsy
Last updated: July 29, 2026
11 Min Read
Pharmacist and clinician discussing pediatric medication options with a parent
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Sertraline

Contents
  • Mood swings
  • Drowsiness
  • Nausea
  • Diarrhea
  • Angle-closure glaucoma
  • Serotonin syndrome
  • Interactions with other medications

Whether you have recently been prescribed Sertraline for depression, or you’re a long-time user, there are certain things you should know about its side effects. Below are a few common ones:

Mood swings

Mood swings are a common occurrence for many people with anxiety and depression. It’s important to know how to treat them. There are several medications available to help you get back on track. These include:

Zoloft. Zoloft is an antidepressant used to treat anxiety and depression. It can also help with panic attacks. It may also improve sleep, which can improve mood.

Sertraline is part of a class of drugs known as selective serotonin reuptake inhibitors (SSRIs). These drugs raise serotonin levels in the brain. It is a good idea to know which SSRIs you are taking. Taking the wrong medication can result in serious side effects.

Zoloft is the best medication to take if you have depression or anxiety. It may also help with premenstrual dysphoric disorder (PDD), which is a condition that occurs before a woman’s menstrual cycle. Mood stabilizers may also help keep a manic episode from happening.

You should also be aware of the most common side effects of Zoloft. Common side effects include drowsiness, low sodium levels in the blood, and swelling of the throat and lips.

In fact, the FDA requires that all antidepressants carry a boxed warning. The most common side effect of all SSRIs is the serotonin syndrome, which is not a fun experience.

Drowsiness

Taking a sertraline based antidepressant may cause you to sleep like a baby or worse, depending on how you take it. The best way to avoid this is to drink plenty of water while taking this drug. You can also ask your doctor about safe alcohol consumption. Taking this medication is not a good time to drive or operate heavy machinery. Its effects on sleep are largely mitigated by taking it in the morning.

This is a complex drug, and you can expect to experience some sertraline side effects. Some of these side effects are less serious than others. The most common sertraline side effects include: drowsiness, restless leg syndrome, a dry mouth, and nausea. These side effects tend to go away as the drug reaches steady state. Taking it as directed is the best way to avoid sertraline-related side effects. Taking sertraline for too long can also lead to sertraline withdrawal. A sertraline prescription should only be used by adults and should not be given to children. You should not take it with other drugs or alcohol. It is possible to take Antabuse in liquid form, but it is not recommended. Taking sertraline in liquid form will skew the effectiveness of the drug.

Nausea

Symptoms of anxiety and depression can be treated with the help of selective serotonin reuptake inhibitors (SSRIs). These drugs increase the level of serotonin in the brain. These medications are used to treat disorders like depression, obsessive-compulsive disorder, and premenstrual dysphoric disorder.

A number of different drugs can be used to treat the symptoms of these disorders. Sertraline is one of these drugs. These medications increase the level of serotonin in your brain, which helps to maintain your mental balance. However, they can also have some negative side effects.

The most common side effect of sertraline is nausea. This usually happens when you first start taking the drug. However, it can also happen after you’ve been taking it for several weeks.

It’s important to talk to your doctor about any side effects you experience while taking sertraline. You may be able to treat them with supplements. However, it’s important to talk to your doctor before you begin taking any supplements.

It’s also important to inform your doctor about all of your current medications. He or she may recommend switching to another antidepressant if you experience serious side effects from sertraline. You may also need to change the dose of sertraline.

Diarrhea

Among the side effects of sertraline is diarrhea. Although diarrhea may be a sign of an underlying illness, it may also be a sign of a viral infection. It is important to treat any infection promptly and not to ignore it.

Diarrhea may be treated with over-the-counter medications or a visit to your physician. Other possible treatments include adding more probiotics to your diet, which are beneficial bacteria that maintain a healthy digestive tract.

Diarrhea that lasts more than a few days is a sign of a more serious ailment. Some parasites in the body can have a major impact on the digestive tract. Other causes of diarrhea are food intolerance and viral infections.

The best way to combat diarrhea is to drink lots of water and to keep your stomach filled with liquids. If your diarrhea is not relieved by these methods, your healthcare provider may recommend a different medication.

Sertraline is a member of a group of medications called selective serotonin reuptake inhibitors (SSRIs). Other medications with a similar effect include antipsychotics, blood thinners, and NSAIDs. These medications can also cause life-threatening bleeding, and you should let your healthcare provider know if you are taking any of these medications.

Angle-closure glaucoma

Despite a lack of evidence about the cause of angle-closure glaucoma, there are several medications that may have a direct effect on the eye. These include adrenergics, anti-cholinergics, and drugs that increase intraocular pressure. Some of these drugs may induce closed-angle glaucoma. Others may have an indirect effect.

There is evidence that SSRIs such as fluoxetine may be associated with glaucoma. In addition, some anti-cholinergics, such as cyclopentolate, atropine, and trifluoperazine, can cause closed-angle glaucoma.

ACG occurs in approximately 1 in 1000 people with Caucasian ancestry. It also occurs in Asians, Hispanics, and Inuits. In fact, it is believed to be the most common cause of permanent blindness.

Drug-induced AACG is a serious ophthalmic emergency. It is caused by a rise in intraocular pressure, which can result in rapid blindness. It can be prevented in susceptible individuals. Symptoms include conjunctival hyperemia, colored halos, and ocular pain.

SSRIs such as fluoxetine, amitriptyline, and imipramine have all been associated with acute angle-closure glaucoma. These drugs are weak anti-cholinergics. They have been shown to relax the pupil sphincter muscle, which can then push the iris and lens forward. This swollen structure may also block the drain of the eye, causing increased intraocular pressure.

Serotonin syndrome

Symptoms of serotonin syndrome can range from mild to life-threatening. If you think you may be suffering from this condition, see a physician immediately.

Serotonin is a neurotransmitter that regulates behavior, body temperature, and the nervous system. Serotonin is primarily found in the brain and intestines. It is also produced by nerve cells in other parts of the body.

Serotonin syndrome is a serious reaction to medications that affect the production of serotonin. If you experience symptoms after taking a serotonergic medication, you should seek medical attention immediately.

Serotonin syndrome can occur from a single dose of a serotonergic drug or it can be a side effect of other medications. Serotonin syndrome can be diagnosed by a doctor based on a medical history and physical exam. It is important to tell your doctor about all the medications you are taking.

If your doctor suspects serotonin syndrome, lab tests may be performed. These tests will help rule out other disorders that look similar to serotonin syndrome. A patient may also be required to drink intravenous fluids and receive breathing support. A cooling bath may also help bring the body’s temperature down.

Serotonin syndrome is characterized by a rapid onset of symptoms. Most cases begin within 24 hours of taking a serotonergic medication. In some cases, the symptoms can progress to coma or kidney failure.

Interactions with other medications

Taking sertraline (Zoloft) with other medications may cause severe adverse effects. Sertraline is in the selective serotonin reuptake inhibitor (SSRI) drug class and is used to treat major depressive disorder and panic disorder.

Taking sertraline with other drugs that increase serotonin levels may increase the risk of serotonin syndrome. This is a potentially life-threatening condition that includes symptoms of agitation, tremor, diaphoresis, confusion, hallucinations, and loss of muscle coordination.

Sertraline may also increase the effect of other medications, including aspirin, ibuprofen, and warfarin. This may increase the risk of bleeding. If you are taking warfarin or aspirin, discuss the use of sertraline with your doctor.

Sertraline can also cause a type of irregular heartbeat called QT prolongation. This may lead to fainting or sudden death. If you notice any symptoms of QT prolongation, discontinue sertraline immediately.

Sertraline is also contraindicated in patients who have a history of seizures. People who have a history of bipolar disorder or mania should also be monitored carefully.

Sertraline should not be taken with monoamine oxidase inhibitors (MAOIs), such as phenelzine. Also, it should not be taken with pimozide (pim), a drug used to treat Tourette’s syndrome. Sertraline is also contraindicated when taken with alcohol, as it may cause an alcohol-disulfiram reaction.

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